Ubiquitin Isopeptidase-IN-G5

CAS No. 108477-18-5

Ubiquitin Isopeptidase-IN-G5 ( NSC-144303;NSC 144303;NSC144303 )

Catalog No. M10333 CAS No. 108477-18-5

A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 82 Get Quote
10MG 141 Get Quote
25MG 306 Get Quote
50MG 541 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Ubiquitin Isopeptidase-IN-G5
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.
  • Description
    A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases; induce a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.
  • Synonyms
    NSC-144303;NSC 144303;NSC144303
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    108477-18-5
  • Formula Weight
    414.39
  • Molecular Formula
    C19H14N2O7S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    O=C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)/C(CS1(=O)=O)=C/C3=CC=C([N+]([O-])=O)C=C3
  • Chemical Name
    4H-Thiopyran-4-one, tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-, 1,1-dioxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.
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